Bromazolam CAS 71368-80-4

CAS No.71368-80-4

Chemical Name: Bromazolam

Bromazolam is classified as a novel benzodiazepine which was first synthesised in 1976, but was never marketed. It has subsequently been sold as a designer drug, first being definitively identified by the EMCDDA in Sweden in 2016. It is the bromo instead of chloro analogue of alprazolam, and has similar sedative and anxiolytic effects. Bromazolam is structurally similar to traditional benzodiazepines, including alprazolam (replacing the chlorine with a bromine) and bromazepam (addition of triazole ring). Alprazolam and bromazepam are Schedule IV substances in the United States; bromazolam is not explicitly scheduled.

Synonyms Bromazola; 8-Bromo-1-methyl-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine; 8-BROMO-1-METHYL-6-PHENYL-4H-BENZO[F][1,2,4]TRIAZOLO[4,3-A][1,4]DIAZEPINE; Bromazolam; Bromazolon; New Bromazolam; Dechlorothiazole; Bromazolam 71368-80-four; 8-Bromo-1-methyl-6-phenyl-4H-; Bromazolam/8-Bromo-1-methyl-6-phenyl-4H-

CBNumber: CB12657919

Molecular Formula: C17H13BrN4

Molecular Weight:353.22

MDL Number: MFCD28405606

Melting point 272.0-275℃

Boiling point 519.8±60.0 °C(Predicted)

Density 1.54±0.1 g/cm3 (20 ºC 760 Torr)

solubility DMF: 30 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml; Methanol: 1 mg/ml

form A crystalline solid

pka 2.37±0.40(Predicted)

Scientific Applications    

Bromazolam has been widely used in laboratory experiments to study the effects of benzodiazepines on bromazolam. It has been used to study the effects of benzodiazepines on memory, learning and behavior. Bromazolam has also been used to study the effects of benzodiazepines on anxiety and depression and their potential therapeutic use in the treatment of these disorders. In addition, bromazolam has been used to study the effects of benzodiazepines on the cardiovascular system and their potential use in the treatment of cardiovascular disease.
Mechanism of action    

The mechanism of action of bromazolam is similar to that of other benzodiazepines. It binds to the gamma-aminobutyric acid (GABA) receptor, a neurotransmitter receptor found in the brain. When bromazolam binds to the GABA receptor, it results in an increased affinity for GABA, which leads to increased inhibition of GABA in nerve cells in the brain. This inhibition of nerve cells produces a sedative effect.
Biochemical and Physiological Effects

The biochemical and physiological effects of bromazolam have been extensively studied in laboratory experiments. The most common effects of bromazolam are sedation, muscle relaxation and anxiolysis. Bromazolam has also been found to have anticonvulsant effects as well as anti-inflammatory effects. In addition, bromazolam has been found to have protective effects against oxidative stress.

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