Introduction to the lidocaine project

Name

Lidocaine

Synonyms

Xylocaine
Maricaine
Lidocaine
Lignocaine
Ligoncaine
2-diethylaminoacet-2,6-xylidide
6'-acetoxylidide,2-(diethylamino)-2
2-(Diethylamino)-2',6'-acetoxylidide
2-(diethylamino)-2',6'-acetoxylidide
2',6'-Acetoxylidide, 2-(diethylamino)-
2-(diethylamino)-n-(2,6-dimethylphenyl)-acetamid
2-(Diethylamino)-N-(2,6-dimethylphenyl)-acetamide
Acetamide, 2-(diethylamino)-N-(2,6-dimethylphenyl)-
N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide
2-[(2,6-dimethylphenyl)amino]-N,N-diethyl-2-oxoethanaminium

CAS

137-58-6

EINECS

205-302-8

InChI

InChI=1/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H, 5-6, 10H2, 1-4H3, (H, 15, 17)/p+1

InChIKey

NNJVILVZKWQKPM-UHFFFAOYSA-N

Molecular Formula

C14H22N2O

Molar Mass

234.34

Density

0.9944 (rough estimate)

Melting Point

66-69°C

Boling Point

bp4 180-182°; bp2 159-160°

Flash Point

9℃

Water Solubility

practically insoluble

Solubility

ethanol: 4mg/mL

Vapor Presure

4.28E-05mmHg at 25°C

Appearance

powder

Color

White to slightly yellow

Merck

14,5482

pKa

pKa 7.88(H2O)(Approximate)

Storage Condition

Store at RT

Stability

Stable. Incompatible with strong oxidizing agents.

Refractive Index

1.5110 (estimate)

Physical and Chemical Properties

White needle-like crystals. Melting point 68-69 ℃; Boiling point 180-182 ℃(0.53kPa),159-160 ℃(0.267kPa) soluble in ethanol, ether, benzene, chloroform and oil, insoluble in water. Commonly used base hydrochloride, lidocaine hydrochloride (C14H22N2O. HCL,[73-78-9]) is a white crystalline powder. Melting point 127-129 °c, melting point of the monohydrate 77-78 °c. Very soluble in water, 0.5% aqueous pHO 4.0-5.5. Odorless, with bitter and Hemp taste.

Use

Used as a local anesthetic